Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of the E-cadherin/catenin complex in gastrointestinal cancer.

Acta gastro-enterologica Belgica - 1 Jan 2000

Debruyne P, Vermeulen S, Mareel M

Abstract excerpt

Cancer is a genetic disease. The unstable genome of cancer cells causes tumour progression through multiple alterations in suppressor and promoter genes, leading to loss of homeostatic and gain of oncogenic functions. Invasion is the critical step in the acquisition of malignancy. It implicates a continuous molecular conversation of the cancer cells with other cells and with the extracellular matrix in which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Cadherins
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoskeletal Proteins

Share to Gastrointestinal Neoplasms

Share to Neoplasm Invasiveness

Share to Trans-Activators

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 10692769

Genes

APC
CTNNA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of the E-cadherin/catenin complex in gastrointestinal cancer.PMID 10692769Read ↗

Dysregulation of the E-cadherin/catenin complex by irreversible mutations in human carcinomas.Semantic proximity Read ↗

The interactions of APC, E-cadherin and beta-catenin in tumour development and progression.Semantic proximity Read ↗

Characterization of the E-cadherin/catenin complex in colorectal carcinoma cell lines.Semantic proximity Read ↗

E-cadherin-catenin cell-cell adhesion complex and human cancer.Semantic proximity Read ↗

The role of E-cadherin-catenin complex: more than an intercellular glue?Semantic proximity Read ↗

Cadherin and catenin alterations in human cancer.Semantic proximity Read ↗

Level of α-catenin expression in colorectal cancer correlates with invasiveness, metastatic potential, and survivalSemantic proximity Read ↗

The alphaE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells.Semantic proximity Read ↗

E-cadherin can limit the transforming properties of activating β-catenin mutations.Semantic proximity Read ↗

Disrupting ß-catenin dependent Wnt signaling activates an invasive gene program predictive of colon cancer progressionSemantic proximity Read ↗

Epithelial-Mesenchymal Transitions in Cancer ProgressionSemantic proximity Read ↗

A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.