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Article

A short-term colorectal cancer sphere culture as a relevant tool for human cancer biology investigation

28 Mar 2013

Abstract excerpt

BACKGROUND: Ex vivo colospheres have been previously characterised as a colorectal cancer (CRC) well-rounded multicellular model, exclusively formed by carcinoma cells, and derived from fresh CRC tissue after mechanical dissociation. The ability to form colospheres was correlated with tumour aggressiveness. Their three-dimensional conformation prompted us to further investigate their potential interest as a...

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PMID: 23538387
DOI: 10.1038/bjc.2013.132

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