Article
Plakoglobin induces desmosome formation and epidermoid phenotype in N-cadherin-expressing squamous carcinoma cells deficient in plakoglobin and E-cadherin.
Cell motility and the cytoskeleton - 1 Jan 1998
Parker H R, Li Z, Sheinin H, Lauzon G, Pasdar M
Abstract excerpt
Pg is a homologue of beta-catenin and Armadillo, the product of the Drosophila segment polarity gene and has been shown to have both adhesive and signaling functions. It interacts with both classic and desmosomal cadherins. Pg interaction with the desmosomal cadherins is essential for desmosome a...
Topics
- Cadherins
- Carcinoma, Squamous Cell
- Cell Adhesion
- Cell Division
- Cytoskeletal Proteins
- Desmoplakins
- Desmosomes
- Epithelial Cells
- Gene Expression
- Humans
- Phenotype
- Trans-Activators
- Tumor Cells, Cultured
- alpha Catenin
- beta Catenin
- gamma Catenin