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Article

Type I collagen inhibits differentiation and promotes a stem cell-like phenotype in human colorectal carcinoma cells

30 Jun 2009

Abstract excerpt

BACKGROUND: Human colorectal cancer is caused by mutations and is thought to be maintained by a population of cancer stem cells. Further phenotypic changes occurring at the invasive edge suggest that colon cancer cells are also regulated by their microenvironment. Type I collagen, a promoter of the malignant phenotype in pancreatic carcinoma cells, is highly expressed at the invasive front of human colorectal...

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PMID: 19568234
DOI: 10.1038/sj.bjc.6605143

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