Article
Loss of E-cadherin is not a necessity for epithelial to mesenchymal transition in human breast cancer.
Breast cancer research and treatment - 1 Feb 2013
Hollestelle Antoinette, Peeters Justine K, Smid Marcel, Timmermans Mieke, Verhoog Leon C, Westenend Pieter J, Heine Anouk A J, Chan Alan, Sieuwerts Anieta M, Wiemer Erik A C, Klijn Jan G M, van der Spek Peter J, Foekens John A, Schutte Mieke, den Bakker Michael A, Martens John W M
Abstract excerpt
Epithelial to mesenchymal transition (EMT) is typically defined by the acquisition of a spindle cell morphology in combination with loss of E-cadherin and upregulation of mesenchymal markers. However, by studying E-cadherin inactivation in 38 human breast cancer cell lines, we noted that not all cell lines that had undergone EMT had concomitantly lost E-cadherin expression. We further investigated this...
Topics
- Breast Neoplasms
- Cadherins
- Cell Line, Tumor
- Epithelial-Mesenchymal Transition
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Humans
- Mutation