Article
Exclusion from spheroid formation identifies loss of essential cell-cell adhesion molecules in colon cancer cells.
Scientific reports - 18 Jan 2018
Stadler Mira, Scherzer Martin, Walter Stefanie, Holzner Silvio, Pudelko Karoline, Riedl Angelika, Unger Christine, Kramer Nina, Weil Beatrix, Neesen Jürgen, Hengstschläger Markus, Dolznig Helmut
Abstract excerpt
Many cell lines derived from solid cancers can form spheroids, which recapitulate tumor cell clusters and are more representative of the in vivo situation than 2D cultures. During spheroid formation, a small proportion of a variety of different colon cancer cell lines did not integrate into the sphere and lost cell-cell adhesion properties. An enrichment protocol was developed to augment the proportion of these...
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