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Article

Absence of p300 induces cellular phenotypic changes characteristic of epithelial to mesenchyme transition.

British journal of cancer - 8 May 2006

Krubasik D, Iyer N G, English W R, Ahmed A A, Vias M, Roskelley C, Brenton J D, Caldas C, Murphy G

Abstract excerpt

p300 is a transcriptional cofactor and prototype histone acetyltransferase involved in regulating multiple cellular processes. We generated p300 deficient (p300-) cells from the colon carcinoma cell line HCT116 by gene targeting. Comparison of epithelial and mesenchymal proteins in p300- with parental HCT116 cells showed that a number of genes involved in cell and extracellular matrix interactions, typical of...

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Identifiers

PMID: 16622451
DOI: 10.1038/sj.bjc.6603101
PMCID: PMC2361417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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