Article
Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America - 2 Mar 1999
Efstathiou J A, Liu D, Wheeler J M, Kim H C, Beck N E, Ilyas M, Karayiannakis A J, Mortensen N J, Kmiot W, Playford R J, Pignatelli M, Bodmer W F
Abstract excerpt
Epithelial (E)-cadherin and its associated cytoplasmic proteins (alpha-, beta-, and gamma-catenins) are important mediators of epithelial cell-cell adhesion and intracellular signaling. Much evidence exists suggesting a tumor/invasion suppressor role for E-cadherin, and loss of expression, as well as mutations, has been described in a number of epithelial cancers. To investigate whether E-cadherin gene (CDH1)...
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