Article
hMSH6 deficiency and inactivation of the alphaE-catenin invasion-suppressor gene in HCT-8 colon cancer cells.
Clinical & experimental metastasis - 1 Jan 1999
Vermeulen S J, Debruyne P R, Marra G, Speleman F P, Boukamp P, Jiricny J, Cuthbert A P, Newbold R F, Nollet F H, van Roy F M, Mareel M M
Abstract excerpt
Transition from an epithelioid (E) to a round (R) morphotype, in the human colon cancer cell line HCT-8, is associated with loss or truncation of alphaE-catenin and acquisition of invasiveness in organ culture. In E clones, like in parental HCT-8 cells, one allele of the alphaE-catenin gene (CTNNA1) is mutated. HCT-8 cells have also a 'Microsatelite Instability-High' (MSI-H) phenotype presumably due to a mutated...
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