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Article

Regulation of in vitro fibril formation of synuclein mutant proteins by Hsp104p.

Protein and peptide letters - 1 Oct 2003

Kong Byungmoon, Chae Young Kee, Lee Kyunghee

Abstract excerpt

Hsp104p, as an anti-oxidative protector of ROS generation, was examined to inquire if it prevents aggregation of synuclein mutants, A30P or A53T upon aging, in vitro. The role of Hsp104p was also addressed in dissociation of pre-formed aggregates of synuclein mutants. Significant protection in fibril formation was observed by wild-type Hsp104p regardless of ATP presence, not by mutant Hsp104p. To a lesser extent,...

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Identifiers

PMID: 14561138
DOI: 10.2174/0929866033478717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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