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Article

Human Molecular Chaperone Hsp60 and Its Apical Domain Suppress Amyloid Fibril Formation of α-Synuclein.

International journal of molecular sciences - 19 Dec 2019

Yamamoto Hanae, Fukui Naoya, Adachi Mayuka, Saiki Eiichi, Yamasaki Anna, Matsumura Rio, Kuroyanagi Daichi, Hongo Kunihiro, Mizobata Tomohiro, Kawata Yasushi

Abstract excerpt

Heat shock proteins play roles in assisting other proteins to fold correctly and in preventing the aggregation and accumulation of proteins in misfolded conformations. However, the process of aging significantly degrades this ability to maintain protein homeostasis. Consequently, proteins with incorrect conformations are prone to aggregate and accumulate in cells, and this aberrant aggregation of misfolded...

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Identifiers

PMID: 31861692
DOI: 10.3390/ijms21010047
PMCID: PMC6982183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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