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Article

Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease.

Journal of molecular biology - 2 Sept 2005

Flower Todd R, Chesnokova Liudmila S, Froelich Clifford A, Dixon Cheryl, Witt Stephan N

Abstract excerpt

We show that human wild-type alpha synuclein (WT alpha-syn), and the inherited mutants A53T or A30P, when expressed in the yeast Saccharomyces cerevisiae triggers events that are diagnostic of apoptosis: loss of membrane asymmetry due to the externalization of phosphatidylserine, accumulation of reactive oxygen species (ROS), and the release of cytochrome c from mitochondria. A brief heat shock was strikingly...

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Identifiers

PMID: 16051265
DOI: 10.1016/j.jmb.2005.06.060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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