Article

Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism

2020-05-16

Abstract excerpt

Over-expression and aggregation of α-synuclein (ASyn) are linked to the onset and pathology of Parkinson’s disease and related synucleinopathies. Elevated levels of the stress induced chaperone, Hsp70, protects against ASyn misfolding and ASyn-driven neurodegeneration in cell and animal models, yet there is minimal mechanistic understanding of this important protective pathway. It is generally assumed that Hsp70 b...

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Literature Corpus work: a20e5e3c-5d7d-53d0-bf66-09618562468d
DOI: 10.1101/2020.05.15.098699

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