Article
Protective effect of TAT-delivered alpha-synuclein: relevance of the C-terminal domain and involvement of HSP70.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2004
Albani Diego, Peverelli Erika, Rametta Raffaela, Batelli Sara, Veschini Lorenzo, Negro Alessandro, Forloni Gianluigi
Abstract excerpt
Alpha-synuclein (alpha-syn) is a 140-amino acid presinaptic protein whose mutations A30P and A53T have been linked to familiar Parkinson's disease (PD). Many data suggest that alpha-syn aggregation is the key event that triggers alpha-syn-mediated neurotoxicity. Nevertheless, other lines of evide...
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