Article
The p7 polypeptide of hepatitis C virus is critical for infectivity and contains functionally important genotype-specific sequences.
Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2003
Sakai Akito, Claire Marisa St, Faulk Kristina, Govindarajan Sugantha, Emerson Suzanne U, Purcell Robert H, Bukh Jens
Abstract excerpt
The role of the hepatitis C virus (HCV) p7 protein in the virus life cycle is not known. Previous in vitro data indicated that this 63-aa polypeptide is located in the endoplasmic reticulum and has two transmembrane domains (TMDs) connected by a cytoplasmic loop; the amino- and carboxyl-terminal tails are oriented toward the endoplasmic reticulum lumen. Furthermore, recent in vitro studies suggested that HCV p7...
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