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Article

Hepatitis C virus nonstructural protein 5B is involved in virus morphogenesis.

Journal of virology - 1 May 2012

Gouklani Hamed, Bull Rowena A, Beyer Claudia, Coulibaly Fasséli, Gowans Eric J, Drummer Heidi E, Netter Hans J, White Peter A, Haqshenas Gholamreza

Abstract excerpt

The p7 protein of hepatitis C virus (HCV) is a viroporin that is dispensable for viral genome replication but plays a critical role in virus morphogenesis. In this study, we generated a JFH1-based intergenotypic chimeric genome that encoded a heterologous genotype 1b (GT1b) p7. The parental intergenotypic chimeric genome was nonviable in human hepatoma cells, and infectious chimeric virions were produced only...

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Source

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Identifiers

PMID: 22345449
DOI: 10.1128/JVI.07089-11
PMCID: PMC3347352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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