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Article

Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel.

Hepatology (Baltimore, Md.) - 1 Dec 2008

Griffin Stephen, Stgelais Corine, Owsianka Ania M, Patel Arvind H, Rowlands David, Harris Mark

Abstract excerpt

UNLABELLED: The hepatitis C virus (HCV) p7 protein plays a critical role during particle formation in cell culture and is required for virus replication in chimpanzees. The discovery that it displayed cation channel activity in vitro led to its classification within the "viroporin" family of virus-coded ion channel proteins, which includes the influenza A virus (IAV) M2 protein. Like M2, p7 was proposed as a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18828153
DOI: 10.1002/hep.22555
PMCID: PMC7615706

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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