Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alanine scanning of the hepatitis C virus core protein reveals numerous residues essential for production of infectious virus.

Journal of virology - 1 Oct 2007

Murray Catherine L, Jones Christopher T, Tassello Jodie, Rice Charles M

Abstract excerpt

Hepatitis C virus (HCV) is an important human pathogen affecting an estimated 3% of the world's population. Recent advances have enabled in vitro propagation of the virus and allow assembly and egress to be investigated for the first time. As a component of the virion, the HCV core protein likely functions primarily in infectious virus production, although little is known about the determinants of this activity....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to Genome, Viral
Share to Hepacivirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis, Site-Directed

Share to Serine

Share to Viral Core Proteins

Share to Virion

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 17634240
DOI: 10.1128/JVI.00793-07
PMCID: PMC2045476

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alanine scanning of the hepatitis C virus core protein reveals numerous residues essential for production of infectious virus.PMID 17634240Read ↗

A genetic interaction between the core and NS3 proteins of hepatitis C virus is essential for production of infectious virus.Semantic proximity Read ↗

Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions.Semantic proximity Read ↗

Identification of basic amino acids at the N-terminal end of the core protein that are crucial for hepatitis C virus infectivity.Semantic proximity Read ↗

Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus.Semantic proximity Read ↗

The hepatitis C virus NS4B protein can trans-complement viral RNA replication and modulates production of infectious virus.Semantic proximity Read ↗

Hepatitis C Virus: Assembly and Release of Virus ParticlesSemantic proximity Read ↗

Structural biology of hepatitis C virusSemantic proximity Read ↗

A role for domain I of the hepatitis C virus NS5A protein in virus assemblySemantic proximity Read ↗

Unravelling hepatitis C virus replication from genome to functionSemantic proximity Read ↗

A Comprehensive Functional Map of the Hepatitis C Virus Genome Provides a Resource for Probing Viral ProteinsSemantic proximity Read ↗

Regulation of the production of infectious genotype 1a hepatitis C virus by NS5A domain III.Semantic proximity Read ↗

The acidic domain of the hepatitis C virus NS4A protein is required for viral assembly and envelopment through interactions with the viral E1 glycoprotein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.