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Article

Hepatitis C Virus p7 is Critical for Capsid Assembly and Envelopment

2 May 2013

Abstract excerpt

Hepatitis C virus (HCV) p7 is a membrane-associated ion channel protein crucial for virus production. To analyze how p7 contributes to this process, we dissected HCV morphogenesis into sub-steps including recruitment of HCV core to lipid droplets (LD), virus capsid assembly, unloading of core protein from LDs and subsequent membrane envelopment of capsids. Interestingly, we observed accumulation of slowly...

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PMID: 23658526
DOI: 10.1371/journal.ppat.1003355

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