Article
Hepatitis C virus p7: molecular function and importance in hepatitis C virus life cycle and potential antiviral target.
Liver international : official journal of the International Association for the Study of the Liver - 1 May 2011
Khaliq Saba, Jahan Shah, Hassan Sajida
Abstract excerpt
p7, a 63-residue peptide encoded by hepatitis C virus (HCV), a major pathogen associated with a risk of developing severe liver disease, is involved in ion channel activity in lipid bilayer membranes both in in vitro and cell-based assays. p7 protein consists of two transmembrane α-helices, TM1 and TM2 connected by a loop oriented towards the cytoplasm. HCV relies on p7 function in addition to ion channel...
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