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Article

Functional analyses of GB virus B p13 protein: development of a recombinant GB virus B hepatitis virus with a p7 protein.

Proceedings of the National Academy of Sciences of the United States of America - 28 Feb 2006

Takikawa Shingo, Engle Ronald E, Emerson Suzanne U, Purcell Robert H, St Claire Marisa, Bukh Jens

Abstract excerpt

GB virus B (GBV-B), which infects tamarins, is the virus most closely related to hepatitis C virus (HCV). HCV has a protein (p7) that is believed to form an ion channel. It is critical for viability. In vitro studies suggest that GBV-B has an analogous but larger protein (p13). We found that substitutions of the -1 and/or -3 residues of the putative cleavage sites (amino acid 613/614 and 732/733) abolished...

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Identifiers

PMID: 16492760
DOI: 10.1073/pnas.0511297103
PMCID: PMC1413929

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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