Article
Mutations in hepatitis C virus p7 reduce both the egress and infectivity of assembled particles via impaired proton channel function.
The Journal of general virology - 1 Oct 2013
Bentham Matthew J, Foster Toshana L, McCormick Christopher, Griffin Stephen
Abstract excerpt
Hepatitis C virus (HCV) p7 protein is critical for the efficient production of infectious virions in culture. p7 undergoes genotype-specific protein-protein interactions as well as displaying channel-forming activity, making it unclear whether the phenotypes of deleterious p7 mutations result from the disruption of one or both of these functions. Here, we showed that proton channel activity alone, provided in...
Topics
- Carrier Proteins
- Cell Line, Tumor
- Gene Expression Regulation, Viral
- Hepacivirus
- Humans
- Ion Channels
- Mutation
- Protons
- Viral Proteins
- Virion
- Virus Assembly