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Article

Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus.

Journal of virology - 1 Aug 2007

Jones Christopher T, Murray Catherine L, Eastman Dawnnica K, Tassello Jodie, Rice Charles M

Abstract excerpt

Hepatitis C virus (HCV) infection is a global health concern affecting an estimated 3% of the world's population. Recently, cell culture systems have been established, allowing recapitulation of the complete virus life cycle for the first time. Since the HCV proteins p7 and NS2 are not predicted to be major components of the virion, nor are they required for RNA replication, we investigated whether they might...

Topics

Cells, Cultured
Conserved Sequence
Genes, Reporter
Hepacivirus
Humans
Ion Channels
Luciferases
Mutation
Viral Nonstructural Proteins
Viral Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17537845
DOI: 10.1128/JVI.00690-07
PMCID: PMC1951341

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