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Article

Drosophila screening model for metastasis: Semaphorin 5c is required for l(2)gl cancer phenotype.

Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2003

Woodhouse Elisa C, Fisher Amy, Bandle Russell W, Bryant-Greenwood Bianca, Charboneau Lula, Petricoin Emanuel F, Liotta Lance A

Abstract excerpt

Cancer metastasis is a complex process involving many genes and pathways. This complexity hinders the identification of molecules functionally required for this process. We have developed and used a Drosophila screening system to identify genes that are functionally important for tumorigenicity and metastasis. Deletion of Drosophila lethal giant larvae (l(2)gl) leads to highly invasive and widely metastatic...

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Identifiers

PMID: 14500904
DOI: 10.1073/pnas.2031202100
PMCID: PMC208780

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