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Article

Tumorigenic Properties of <i>Drosophila</i> Epithelial Cells Mutant for <i>lethal giant larvae</i>

30 May 2016

Abstract excerpt

BACKGROUND: Mutations in Drosophila tumor suppressor genes (TSGs) lead to the formation of invasive tumors in the brain and imaginal discs. RESULTS: Here we studied the tumorigenic properties of imaginal discs mutant for the TSG gene lethal giant larvae (lgl). lgl mutant cells display the characteristic features of mammalian tumor cells: they can proliferate indefinitely, induce additional tracheogenesis (an...

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PMID: 27239786
DOI: 10.1002/dvdy.24420

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