Article
Growth, metastasis, and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genes.
Development genes and evolution - 1 Feb 1998
Woodhouse E, Hersperger E, Shearn A
Abstract excerpt
More than 50 genes have been identified in Drosophila by loss-of-function mutations that lead to overgrowth of specific tissues. Loss-of-function mutations in the lethal giant larvae, discs large, or brain tumor genes cause neoplastic overgrowth of larval brains and imaginal discs. In the present study, the growth and metastatic potential of tumors resulting from mutations in these genes were quantified....
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