Growth, metastasis, and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genes.

doi:10.1007/s004270050145

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Article

Growth, metastasis, and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genes.

Development genes and evolution - 1 Feb 1998

Woodhouse E, Hersperger E, Shearn A

Abstract excerpt

More than 50 genes have been identified in Drosophila by loss-of-function mutations that lead to overgrowth of specific tissues. Loss-of-function mutations in the lethal giant larvae, discs large, or brain tumor genes cause neoplastic overgrowth of larval brains and imaginal discs. In the present...

Topics

Animals
Brain
Brain Tissue Transplantation
Drosophila
Drosophila Proteins
Female
Genes, Tumor Suppressor
Insect Proteins
Mutation
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasms, Experimental
Tumor Suppressor Proteins

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