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Article

A genetic screen in Drosophila for metastatic behavior.

Science (New York, N.Y.) - 14 Nov 2003

Pagliarini Raymond A, Xu Tian

Abstract excerpt

A genetic screen was designed in Drosophila to interrogate its genome for mutations sufficient to cause noninvasive tumors of the eye disc to invade neighboring or distant tissues. We found that cooperation between oncogenic RasV12 expression and inactivation of any one of a number of genes affecting cell polarity leads to metastatic behavior, including basement membrane degradation, loss of E-cadherin...

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PMID: 14551319
DOI: 10.1126/science.1088474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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