Article
The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily.
Cell - 29 Nov 1991
Mahoney P A, Weber U, Onofrechuk P, Biessmann H, Bryant P J, Goodman C S
Abstract excerpt
Recessive lethal mutations in the fat locus of Drosophila cause hyperplastic, tumor-like overgrowth of larval imaginal discs, defects in differentiation and morphogenesis, and death during the pupal stage. Clones of mutant cells induced by mitotic recombination demonstrate that the overgrowth phe...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Cadherins
- Cloning, Molecular
- Drosophila
- Ectoderm
- Embryo, Nonmammalian
- Genes, Lethal
- Genes, Recessive
- Genes, Tumor Suppressor
- Larva
- Molecular Sequence Data
- Multigene Family
- Polymerase Chain Reaction
- Recombination, Genetic
- Sequence Homology, Nucleic Acid