Article
Genomic analysis of metastasis reveals an essential role for RhoC.
Nature - 3 Aug 2000
Clark E A, Golub T R, Lander E S, Hynes R O
Abstract excerpt
The most damaging change during cancer progression is the switch from a locally growing tumour to a metastatic killer. This switch is believed to involve numerous alterations that allow tumour cells to complete the complex series of events needed for metastasis. Relatively few genes have been implicated in these events. Here we use an in vivo selection scheme to select highly metastatic melanoma cells. By...
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