Article
The internalization signal in the cytoplasmic tail of lysosomal acid phosphatase consists of the hexapeptide PGYRHV.
The EMBO journal - 1 Dec 1992
Lehmann L E, Eberle W, Krull S, Prill V, Schmidt B, Sander C, von Figura K, Peters C
Abstract excerpt
Lysosomal acid phosphatase (LAP) is rapidly internalized from the cell surface due to a tyrosine-containing internalization signal in its 19 amino acid cytoplasmic tail. Measuring the internalization of a series of LAP cytoplasmic tail truncation and substitution mutants revealed that the N-termi...
Topics
- Acid Phosphatase
- Alanine
- Amino Acid Sequence
- Animals
- Cells, Cultured
- Cricetinae
- Endocytosis
- Fluorescent Antibody Technique
- Kinetics
- Lysosomes
- Molecular Sequence Data
- Mutation
- Oligopeptides
- Protein Conformation