Article
Phosphorylation-dependent down-modulation of CD4 requires a specific structure within the cytoplasmic domain of CD4.
The Journal of biological chemistry - 5 Jun 1991
Shin J, Dunbrack R L, Lee S, Strominger J L
Abstract excerpt
Several structural features of the cytoplasmic domain of CD4 including phosphorylation of Ser-408 have been shown to be important in its endocytosis (Shin, J., Doyle, C., Yang, Z., Kappes, D., and Strominger, J.L. (1990) EMBO J. 9, 425-434). A series of cytoplasmic domain truncations have now ind...
Topics
- Amino Acid Sequence
- CD4 Antigens
- CD4-Positive T-Lymphocytes
- Down-Regulation
- Electrophoresis, Polyacrylamide Gel
- Endocytosis
- Humans
- Microscopy, Fluorescence
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Precipitin Tests
- Protein Conformation
- Protein-Tyrosine Kinases
- Sequence Homology, Nucleic Acid