Article
Accumulation of membrane glycoproteins in lysosomes requires a tyrosine residue at a particular position in the cytoplasmic tail.
The Journal of cell biology - 1 Sept 1990
Williams M A, Fukuda M
Abstract excerpt
Human lysosome membrane glycoprotein h-lamp-1 is a highly N-glycosylated protein found predominantly in lysosomes, with low levels present at the cell surface. The signal required for delivery of h-lamp-1 to lysosomes was investigated by analyzing the intracellular distribution of h-lamp-1 with a...
Topics
- Amino Acid Sequence
- Antigens, CD
- Biological Transport
- Cell Membrane
- Cells, Cultured
- Chorionic Gonadotropin
- Humans
- Lysosomal Membrane Proteins
- Lysosomes
- Membrane Glycoproteins
- Molecular Sequence Data
- Mutation
- Protein Sorting Signals
- Recombinant Fusion Proteins
- Tyrosine