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Article

The dileucine motif within the tail of MPR46 is required for sorting of the receptor in endosomes.

Traffic (Copenhagen, Denmark) - 1 Aug 2000

Tikkanen R, Obermüller S, Denzer K, Pungitore R, Geuze H J, von Figura K, Höning S

Abstract excerpt

The cytoplasmic tail of MPR46 carries a leucine-based motif that is required for the sorting of lysosomal enzymes by the receptor. In addition, it is one of three independent, but functionally redundant, internalization signals present in the cytoplasmic tail of MPR46. We have analyzed a mutant of MPR46, in which the dileucine pair was replaced by alanines (MPR46 LL/AA) with respect to its intracellular...

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PMID: 11208151
DOI: 10.1034/j.1600-0854.2000.010807.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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