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Article

Internalization of the alpha 5 beta 1 integrin does not depend on "NPXY" signals.

Biochemical and biophysical research communications - 15 Mar 1994

Vignoud L, Usson Y, Balzac F, Tarone G, Block M R

Abstract excerpt

The alpha 5 beta 1 integrin is a constitutively internalized fibronectin receptor. It contains in the cytoplasmic tail of its beta 1 subunit two NPXY sequences which have been proposed to mediate internalization. Indeed a NPXY motif constitutes the internalization signal for the Low Density Lipoprotein (LDL) and insulin receptors. To learn more about the putative role of the two NPXY sequences in internalization...

Topics

Amino Acid Sequence
Animals
CHO Cells
Cloning, Molecular
Cricetinae
Fluorescent Antibody Technique
Genetic Variation
Humans
Integrins
Lipoproteins, LDL
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Site-Directed

Receptor, Insulin

Receptors, Fibronectin

Recombinant Proteins

Transfection

Source

Identifiers

PMID: 7510958
DOI: 10.1006/bbrc.1994.1271

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7510958-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Internalization of the alpha 5 beta 1 integrin does not depend on "NPXY" signals.PMID 7510958Read ↗

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.Semantic proximity Read ↗

NPXY motifs control the recruitment of the alpha5beta1 integrin in focal adhesions independently of the association of talin with the beta1 chain.Semantic proximity Read ↗

Regulation of integrin affinity states through an NPXY motif in the beta subunit cytoplasmic domain.Semantic proximity Read ↗

Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis.Semantic proximity Read ↗

Several weak signals in the cytosolic and transmembrane domains of the interleukin-2-receptor beta chain allow for its efficient endocytosis.Semantic proximity Read ↗

Fc receptor endocytosis is controlled by a cytoplasmic domain determinant that actively prevents coated pit localization.Semantic proximity Read ↗

VZV gB endocytosis and Golgi localization are mediated by YXXphi motifs in its cytoplasmic domain.Semantic proximity Read ↗

The cytoplasmic domain is not involved in directing Class 5 mutant LDL receptors to lysosomal degradation.Semantic proximity Read ↗

The NPEY sequence is not necessary for endocytosis and processing of insulin-receptor complexes.Semantic proximity Read ↗

Role of the beta1-integrin cytoplasmic tail in mediating invasin-promoted internalization of Yersinia.Semantic proximity Read ↗

Functional role of the cytoplasmic domain of the integrin alpha 5 subunit.Semantic proximity Read ↗

α <sub>5</sub> β <sub>1</sub> -Integrin controls ebolavirus entry by regulating endosomal cathepsinsSemantic proximity Read ↗

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