Article
Internalization of the alpha 5 beta 1 integrin does not depend on "NPXY" signals.
Biochemical and biophysical research communications - 15 Mar 1994
Vignoud L, Usson Y, Balzac F, Tarone G, Block M R
Abstract excerpt
The alpha 5 beta 1 integrin is a constitutively internalized fibronectin receptor. It contains in the cytoplasmic tail of its beta 1 subunit two NPXY sequences which have been proposed to mediate internalization. Indeed a NPXY motif constitutes the internalization signal for the Low Density Lipoprotein (LDL) and insulin receptors. To learn more about the putative role of the two NPXY sequences in internalization...
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