Article
NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.
The Journal of biological chemistry - 25 Feb 1990
Chen W J, Goldstein J L, Brown M S
Abstract excerpt
Rapid internalization of the cell surface low density lipoprotein (LDL) receptor requires the first 22 amino acids of the cytoplasmic domain (residues 790-811), which must include an aromatic residue at position 807. In the human LDL receptor, this position is part of a tetrameric sequence, NPVY. A similar tetramer, NPXY (where X stands for any amino acid), is conserved in LDL receptors from six species...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Coated Pits, Cell-Membrane
- Cytoplasm
- Endocytosis
- Endosomes
- Humans
- Molecular Sequence Data
- Multigene Family
- Mutation