Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targetting to lysosomes.

Journal of cell science - 1 Jan 2002

Obermüller Stefanie, Kiecke Christina, von Figura Kurt, Höning Stefan

Abstract excerpt

Lamp 1 and lysosomal acid phosphatase (LAP) are lysosomal membrane proteins that harbour a tyrosine-based sorting motif within their short cytoplasmic tails. Lamp 1 is delivered from the trans-Golgi network (TGN) via endosomes directly to lysosomes bypassing the plasma membrane, whereas LAP is indirectly transported to lysosomes and recycles between endosomes and the plasma membrane before being delivered to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acid Phosphatase
Share to CD36 Antigens
Share to Clone Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endosomes

Share to Lysosomal Membrane Proteins

Share to Lysosomes

Share to Neuraminidase

Share to Tyrosine

Source

Identifiers

PMID: 11801736
DOI: 10.1242/jcs.115.1.185

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targetting to lysosomes.PMID 11801736Read ↗

The tyrosine-based lysosomal targeting signal in lamp-1 mediates sorting into Golgi-derived clathrin-coated vesicles.Semantic proximity Read ↗

The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane.Semantic proximity Read ↗

Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.Semantic proximity Read ↗

Accumulation of membrane glycoproteins in lysosomes requires a tyrosine residue at a particular position in the cytoplasmic tail.Semantic proximity Read ↗

Lysosomal and vacuolar sorting: not so different after all!Semantic proximity Read ↗

The internalization signal in the cytoplasmic tail of lysosomal acid phosphatase consists of the hexapeptide PGYRHV.Semantic proximity Read ↗

Mechanism of interaction between leucine-based sorting signals from the invariant chain and clathrin-associated adaptor protein complexes AP1 and AP2.Semantic proximity Read ↗

Basolateral sorting of the coxsackie and adenovirus receptor through interaction of a canonical YXXPhi motif with the clathrin adaptors AP-1A and AP-1B.Semantic proximity Read ↗

Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y-dependent sorting motifs in different pathways.Semantic proximity Read ↗

Unifying Nomenclature for the Isoforms of the Lysosomal Membrane Protein LAMP‐2Semantic proximity Read ↗

Molecular Mechanism for LAMP1 Recognition by Lassa VirusSemantic proximity Read ↗

YXXM motifs in the PDGF-beta receptor serve dual roles as phosphoinositide 3-kinase binding motifs and tyrosine-based endocytic sorting signals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.