Identification of a major cyclic AMP-dependent protein kinase A phosphorylation site within the cytoplasmic tail of the low-density lipoprotein receptor-related protein: implication for receptor-mediated endocytosis.

doi:10.1128/MCB.21.4.1185-1195.2001

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Article

Identification of a major cyclic AMP-dependent protein kinase A phosphorylation site within the cytoplasmic tail of the low-density lipoprotein receptor-related protein: implication for receptor-mediated endocytosis.

Molecular and cellular biology - 1 Feb 2001

Li Y, van Kerkhof P, Marzolo M P, Strous G J, Bu G

Abstract excerpt

The low-density lipoprotein (LDL) receptor-related protein (LRP) is a multiligand endocytic receptor that belongs to the LDL receptor family. Recently, studies have revealed new roles of LDL receptor family members as transducers of extracellular signals. Our previous studies have demonstrated LRP phosphorylation within its cytoplasmic tail, but the nature of LRP phosphorylation and its potential function was...

Topics

Animals
Binding Sites
CHO Cells
Cell Line
Cricetinae
Cyclic AMP-Dependent Protein Kinases
Endocytosis
Enzyme Inhibitors
Humans
In Vitro Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Low Density Lipoprotein Receptor-Related Protein-1

Mutation

Phosphorylation

Protein Serine-Threonine Kinases

Receptors, Immunologic

Receptors, LDL

Recombinant Fusion Proteins

Serine

Source

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Identifiers

PMID: 11158305
DOI: 10.1128/MCB.21.4.1185-1195.2001
PMCID: PMC99572

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