Article
Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR.
The EMBO journal - 1 Aug 1990
Streuli M, Krueger N X, Thai T, Tang M, Saito H
Abstract excerpt
Protein tyrosine phosphorylation is regulated by both protein tyrosine kinases and protein tyrosine phosphatases (PTPases). Recently, the structures of a family of PTPases have been described. In order to study the structure-function relationships of receptor-linked PTPases, we analyzed the effects of deletion and point mutations within the cytoplasmic region of the receptor-linked PTPases, LCA and LAR. We show...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Differentiation
- Base Sequence
- Binding Sites
- Cattle
- Cell Adhesion Molecules
- Chromosome Deletion
- Histocompatibility Antigens
- Leukocyte Common Antigens
- Membrane Glycoproteins