Article
Tumor formation is correlated with expression of beta-catenin-accumulated crypts in azoxymethane-induced colon carcinogenesis in mice.
Cancer science - 1 Apr 2004
Hata Kazuya, Yamada Yasuhiro, Kuno Toshiya, Hirose Yoshinobu, Hara Akira, Qiang Sheng Hong, Mori Hideki
Abstract excerpt
We have reported that beta-catenin-accumulated crypts (BCAC) are independent of aberrant crypt foci (ACF) in the colonic mucosa of rats exposed to colorectal carcinogens, and we suggested that they may be premalignant lesions. In the present study, we performed a comparative study on the formatio...
Topics
- Adenocarcinoma
- Adenoma
- Animals
- Azoxymethane
- Biomarkers, Tumor
- Carcinogens
- Colonic Neoplasms
- Cytoskeletal Proteins
- Genetic Predisposition to Disease
- Intestinal Mucosa
- Mice
- Mice, Inbred AKR
- Mucins
- Neoplasm Proteins
- Specific Pathogen-Free Organisms