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Article

Tumor formation is correlated with expression of beta-catenin-accumulated crypts in azoxymethane-induced colon carcinogenesis in mice.

Cancer science - 1 Apr 2004

Hata Kazuya, Yamada Yasuhiro, Kuno Toshiya, Hirose Yoshinobu, Hara Akira, Qiang Sheng Hong, Mori Hideki

Abstract excerpt

We have reported that beta-catenin-accumulated crypts (BCAC) are independent of aberrant crypt foci (ACF) in the colonic mucosa of rats exposed to colorectal carcinogens, and we suggested that they may be premalignant lesions. In the present study, we performed a comparative study on the formation of the two types of early-appearing lesions (BCAC and ACF), and tumors of the colon in two mouse strains with...

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Identifiers

PMID: 15072589
DOI: 10.1111/j.1349-7006.2004.tb03209.x
PMCID: PMC11158367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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