Article
The importance of normal and abnormal oestrogen receptor in breast cancer.
Cancer surveys - 1 Jan 1992
McGuire W L, Chamness G C, Fuqua S A
Abstract excerpt
We have used the screening techniques of CMC and SSCP of selected PCR fragments, and also gel retardation assays, to discover a number of ER variants in clinical breast cancer tissues. We have found base pair insertions, transitions, and deletions, and deletions of exons 3, 5 and 7. Using a yeast transactivation assay, we have discovered receptors with outlaw function consisting of both dominant positive...
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