Oestrogen receptor mutants and variants in breast cancer.

Abstract excerpt

Oestrogen receptor (ER) status is the only biochemical predictive factor which is routinely measured in breast carcinomas. ER gene mutations can profoundly change the biochemical activity of the protein. If these occurred in vivo, they could be expected to affect breast cancer risk or phenotype, such as endocrine responsiveness. However, no mutations of significance have been described in breast carcinomas. In...

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