Article
Abnormal estrogen receptor in clinical breast cancer.
The Journal of steroid biochemistry and molecular biology - 1 Sept 1992
McGuire W L, Chamness G C, Fuqua S A
Abstract excerpt
We have discovered a number of estrogen receptor variants in clinical breast cancer tissues. We have base-pair insertions, transitions, and deletions of exons 3, 5 and 7. Using a transactivation assay we have discovered receptors with outlaw function consisting of both dominant-positive receptors which are transcriptionally active in the absence of estrogen, and dominant-negative receptors which are...
Topics
- Breast Neoplasms
- Mutation
- Phenotype
- Receptors, Estrogen