Article
Nuclear hormone receptor variants: their role in malignancy and progression to hormone resistance in cancer.
Acta endocrinologica - 1 Jan 1991
Sluyser M
Abstract excerpt
Structural variants of nuclear hormone receptors have been found in tumour tissues. Experimental evidence suggests two ways in which these variants may have oncogenic potential: 1. by suppressing the action of the normal hormone receptor, thereby acting as dominant negative oncogenes; 2. by activating hormone-responsive genes in a hormone-independent manner. These mechanisms may not only contribute to oncogenesis...
Topics
- Cell Nucleus
- Drug Resistance
- Hormones
- Humans
- Mutation
- Neoplasms
- Oncogenes
- Receptors, Cell Surface
- Receptors, Estrogen
- Transcription, Genetic