Article
Estrogen receptor variants in clinical breast cancer.
Molecular endocrinology (Baltimore, Md.) - 1 Nov 1991
McGuire W L, Chamness G C, Fuqua S A
Abstract excerpt
We have used the screening techniques of chemical mismatch cleavage, single stranded conformational polymorphism, and gel retardation to discover a number of estrogen receptor RNA variants in clinical breast cancer tissues. We have found basepair insertions, transitions, and deletions as well as alternative splicing, yielding deletions of exon 3, 5, or 7. Using a yeast transactivation assay we have discovered...
Topics
- Amino Acid Sequence
- Base Sequence
- Breast Neoplasms
- Exons
- Female
- Genetic Variation
- Humans
- Molecular Sequence Data
- Polymerase Chain Reaction
- Receptors, Estrogen