Nuclear hormone receptor variants: their role in malignancy and progression to hormone resistance in cancer.

Article

Nuclear hormone receptor variants: their role in malignancy and progression to hormone resistance in cancer.

Anti-cancer drugs - 1 Dec 1990

Sluyser M

Abstract excerpt

Mutations in functional domains of steroid and thyroid hormone receptors cause these molecules to become constitutive (hormone independent) transactivators of gene transcription. Mutations in, for example, the estrogen receptor (ER) may contribute to the loss of estrogen control of some breast ca...

Topics

Genetic Variation
Humans
Mutation
Neoplasms, Hormone-Dependent
Receptors, Estrogen
Receptors, Progesterone
Receptors, Thyroid Hormone

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.