Article
Role of estrogen receptor variants in the development of hormone resistance in breast cancer.
Clinical biochemistry - 1 Dec 1992
Sluyser M
Abstract excerpt
Recent evidence suggests that the progression to hormone resistance in some breast tumors is due to mutations in the estrogen receptor (ER). Various types of ER variants have been found in breast cancer biopsies and breast cancer cell lines. The ER variants include dominant-positive receptors tha...
Topics
- Animals
- Base Sequence
- Breast Neoplasms
- Estrogens
- Gene Amplification
- Humans
- Mammary Neoplasms, Experimental
- Molecular Sequence Data
- Mutation
- Polymorphism, Restriction Fragment Length
- Receptors, Estrogen
- Transcription, Genetic