Article
Genetic and epigenetic alterations of the estrogen receptor gene and hormone independence in human breast cancer.
Oncology - 1 Dec 1998
Iwase H, Omoto Y, Iwata H, Hara Y, Ando Y, Kobayashi S
Abstract excerpt
The existence of hormone-independent tumors is a substantial problem for the present endocrine treatment of breast cancers. Estrogen receptor (ER) gene mutation can change the biochemical activity of the protein and can affect hormone responsiveness. However, quite a few mutations of significance...
Topics
- Alternative Splicing
- Breast Neoplasms
- DNA, Neoplasm
- Female
- Gene Deletion
- Gene Rearrangement
- Humans
- Methylation
- Mutation
- Neoplasms, Hormone-Dependent
- RNA, Neoplasm
- Receptors, Estrogen