Steroid receptor variants and their potential role in cancer.

Abstract excerpt

Variant forms of steroid receptors that possess altered structure have been described in a number of human cancers. This is particularly true for tumors of the breast, which frequently contain a variety of defective estrogen receptors. Evidence for the existence of steroid receptor variants in human tumors is summarized along with what is known regarding the functional behavior of these aberrant receptors. This...

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