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Article

Fibroblasts transformed by different ras oncogenes show dissimilar patterns of protease gene expression and regulation.

Cancer research - 1 Dec 1992

Zhang J Y, Schultz R M

Abstract excerpt

NIH 3T3 cells transformed by different activated ras genes showed different patterns of protease gene expression, indicating the existence of least two pathways for NIH 3T3 transformation from mutated ras genes. In cells transformed by activated mammalian EJ-ras and chimeric EJ/vHa-ras, high constitutive levels of urokinase plasminogen activator (uPA) mRNA and/or phorbol-12-myristate-13-acetate (PMA) inducibility...

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PMID: 1423314

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