Differential expression of matrix metalloproteinases in activated c-ras-Ha-transfected immortalized human keratinocytes.

doi:10.1038/bjc.1998.119

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Article

Differential expression of matrix metalloproteinases in activated c-ras-Ha-transfected immortalized human keratinocytes.

British journal of cancer - 1 Mar 1998

Meade-Tollin L C, Boukamp P, Fusenig N E, Bowen C P, Tsang T C, Bowden G T

Abstract excerpt

Elevated expression of matrix metalloproteinases (MMPs), a family of secreted proteinases that degrade matrix components of basement membranes and connective tissues, is strongly correlated with malignant expression in various human epithelial cancers and epithelial cancer cell lines. We have tes...

Topics

Animals
Cell Line, Transformed
Cell Transformation, Neoplastic
Collagenases
Disease Progression
Enzyme Induction
Gelatinases
Gene Expression Regulation, Neoplastic
Genes, ras
Humans
Keratinocytes
Matrix Metalloproteinase 2
Matrix Metalloproteinase 7
Matrix Metalloproteinase 9

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Identifiers

PMID: 9514050
DOI: 10.1038/bjc.1998.119
PMCID: PMC2149968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9514050-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Metalloendopeptidases

Mice

Mice, Nude

Neoplasm Invasiveness